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Ob Polyclonal Antibody

Polyclonal antibody

Specification

BYab-16091

  • 50UL $180 100UL $255
  • Delivery: In Stock

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Product introduction>

Host
Reactiveness
Use
Molecular weight (DA)
Immunogen
Synthetic peptide from human protein at AA range: 10-50
Specificity
The antibody detects endogenous Ob
Source
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Background
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008],
Function
disease:Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].,function:May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.,online information:Leptin entry,similarity:Belongs to the leptin family.,subunit:Interacts with SIGLEC6.,
Gene Name
LEP OB OBS
Protein name
Leptin (Obese protein) (Obesity factor)
Abbreviation
Ob
Other name
Leptin (Obese protein;Obesity factor)
Fields
>>Cytokine-cytokine receptor interaction;>>Neuroactive ligand-receptor interaction;>>AMPK signaling pathway;>>JAK-STAT signaling pathway;>>Adipocytokine signaling pathway;>>Non-alcoholic fatty liver disease
Human gene ID
3952
Human protein sequence Database
P41159
Mouse gene ID
16846
Mouse protein sequence database
P41160
Rat gene ID
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).
Storage
-20°C/1 year

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Ob Polyclonal Antibody

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