Molecular weight (DA)
12kD
Immunogen
Synthesized peptide derived from C-C motif chemokine 27 at AA range: 51-100
Specificity
CTACK Polyclonal Antibody detects endogenous levels of CTACK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014],
Function
function:Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.,online information:CCL27 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Testis, thymus, placenta, ovary and skin.,
Protein name
C-C motif chemokine 27
Other name
CCL27; ILC; SCYA27; C-C motif chemokine 27; CC chemokine ILC; Cutaneous T-cell-attracting chemokine; CTACK; ESkine; IL-11 R-alpha-locus chemokine; Skinkine; Small-inducible cytokine A27
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
Human protein sequence Database
Q9Y4X3
Mouse protein sequence database
Q9Z1X0
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Testis, thymus, placenta, ovary and skin.
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