Molecular weight (DA)
17kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human EPGN. AA range:11-60
Specificity
Epigen Polyclonal Antibody detects endogenous levels of Epigen protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Function
function:Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.,similarity:Contains 1 EGF-like domain.,
Other name
EPGN; Epigen; Epithelial mitogen; EPG
Human protein sequence Database
Q6UW88
Mouse protein sequence database
Q924X1
Rat protein sequence database
Cellular localization
[Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .
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