Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from Growth/differentiation factor 3 at AA range: 311-360
Specificity
GDF-3 Polyclonal Antibody detects endogenous levels of GDF-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016],
Function
online information:GDF3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.,
Protein name
Growth/differentiation factor 3
Other name
GDF3; Growth/differentiation factor 3; GDF-3
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q9NR23
Mouse protein sequence database
Q07104
Rat protein sequence database
Cellular localization
Secreted . Cytoplasm . Mainly accumulated in the cytoplasm. .
Tissue expression
Kidney,
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