Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IGFBP6. AA range:101-150
Specificity
IGFBP6 Polyclonal Antibody detects endogenous levels of IGFBP6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,PTM:O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. Major glycoforms consist of 8-16 monosaccharides (by homology to IGFBP6 expressed recombinantly in CHO cells).,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,
Function
function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,PTM:O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. Major glycoforms consist of 8-16 monosaccharides (by homology to IGFBP6 expressed recombinantly in CHO cells).,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,
Protein name
Insulin-like growth factor-binding protein 6
Other name
IGFBP6; IBP6; Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6
Human protein sequence Database
P24592
Mouse protein sequence database
P47880
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Cerebrospinal fluid,Fibroblast,Osteosarcoma,Pancreas,Placen
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