Molecular weight (DA)
90kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human NRG2. AA range:361-410
Specificity
Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010],
Function
domain:ERBB receptor binding is elicited entirely by the EGF-like domain.,domain:The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.,function:Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.,PTM:Extensive glycosylation precedes the proteolytic cleavage.,PTM:Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.,similarity:Belongs to the neuregulin family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,s
Protein name
Pro-neuregulin-2 membrane-bound isoform
Abbreviation
Neuregulin-2
Other name
NRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>ErbB signaling pathway;>>Amyotrophic lateral sclerosis
Human protein sequence Database
O14511
Mouse protein sequence database
P56974
Rat protein sequence database
O35569
Cellular localization
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-2]: Secreted .
Tissue expression
Restricted to the cerebellum in the adult.
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