Molecular weight (DA)
23kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human FGF20. AA range:151-200
Specificity
FGF-20 Polyclonal Antibody detects endogenous levels of FGF-20 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009],
Function
function:Neurotrophic factor that regulates central nervous development and function.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Predominantly expressed in the cerebellum.,
Protein name
Fibroblast growth factor 20
Other name
FGF20; Fibroblast growth factor 20; FGF-20
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Regulation of actin cytoskeleton;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Melanoma;>>Breast cancer;>>Gastric cancer
Human protein sequence Database
Q9NP95
Mouse protein sequence database
Q9ESL9
Rat protein sequence database
Q9EST9
Cellular localization
Secreted .
Tissue expression
Predominantly expressed in the cerebellum.
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