Molecular weight (DA)
14kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Urotensin II. AA range:48-97
Specificity
Urotensin II Polyclonal Antibody detects endogenous levels of Urotensin II protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function
function:Highly potent vasoconstrictor.,similarity:Belongs to the urotensin-2 family.,tissue specificity:Brain specific.,
Abbreviation
Urotensin II
Other name
UTS2; Urotensin-2; Urotensin II; U-II; UII
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
O95399
Mouse protein sequence database
Q9QZQ3
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Brain specific.
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