Molecular weight (DA)
18kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140
Specificity
IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
Function
function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,
Protein name
Interleukin-21
Other name
IL21; Interleukin-21; IL-21; Za11
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Th17 cell differentiation;>>Inflammatory bowel disease
Human protein sequence Database
Q9HBE4
Mouse protein sequence database
Q9ES17
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
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