Molecular weight (DA)
255kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MEGF8. AA range:1243-1292
Specificity
EGFL4 Polyclonal Antibody detects endogenous levels of EGFL4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
Function
similarity:Contains 12 Kelch repeats.,similarity:Contains 2 CUB domains.,similarity:Contains 4 laminin EGF-like domains.,similarity:Contains 5 EGF-like domains.,similarity:Contains 7 PSI domains.,
Protein name
Multiple epidermal growth factor-like domains protein 8
Other name
MEGF8; C19orf49; EGFL4; KIAA0817; Multiple epidermal growth factor-like domains protein 8; Multiple EGF-like domains protein 8; Epidermal growth factor-like protein 4; EGF-like protein 4
Fields
>>Hedgehog signaling pathway
Human protein sequence Database
Q7Z7M0
Mouse protein sequence database
P60882
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein .
Tissue expression
Brain,Pancreas,Plasma,
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