Immunogen
The antiserum was produced against synthesized peptide derived from human CK-1gamma1/2/3. AA range:229-278
Specificity
Casein Kinase Iγ1/2/3 Polyclonal Antibody detects endogenous levels of Casein Kinase Iγ1/2/3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,
Gene Name
CSNK1G1/CSNK1G2/CSNK1G3
Protein name
Casein kinase I isoform gamma-1/2/3
Abbreviation
Casein Kinase Iγ1/2/3
Other name
CSNK1G1; Casein kinase I isoform gamma-1; CKI-gamma 1; CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2; CSNK1G3; Casein kinase I isoform gamma-3; CKI-gamma 3
Fields
>>Hedgehog signaling pathway
Human gene ID
53944/1455/1456
Human protein sequence Database
Q9HCP0/P78368/Q9Y6M4
Mouse gene ID
214897/103236/70425
Mouse protein sequence database
Rat gene ID
64086/65278/64823
Rat protein sequence database
Q62761/Q62762/Q62763
Cellular localization
Cytoplasm.
Tissue expression
Brain,Muscle,Pooled,
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