Molecular weight (DA)
175kD
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Pragmin (phospho Tyr413)
Specificity
Phospho-Pragmin (Y413) Polyclonal Antibody detects endogenous levels of Pragmin protein only when phosphorylated at Y413.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
Tyrosine-protein kinase SgK223
Other name
SGK223; Tyrosine-protein kinase SgK223; Sugen kinase 223
Human protein sequence Database
Q86YV5
Mouse protein sequence database
Q571I4
Rat protein sequence database
Cellular localization
Cytoplasm . Cell junction, focal adhesion . Nucleus . Colocalized with NOTCH1 in the nucleus. .
Tissue expression
Amygdala,Epithelium,Fetal brain,Spleen,
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