Molecular weight (DA)
50kD
Immunogen
Synthetic Peptide of BEST2
Specificity
The antibody detects endogenous BEST2 protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB: 1:500-1000 IHC: 1:200-500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008],
Function
function:Forms calcium-sensitive chloride channels. May conduct other physiologically significant anions such as bicarbonate.,similarity:Belongs to the bestrophin family.,tissue specificity:Mainly confined to the retinal pigment epithelium and colon.,
Protein name
Bestrophin-2
Other name
Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1
Fields
>>Salivary secretion
Human protein sequence Database
Q8NFU1
Mouse protein sequence database
Q8BGM5
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Mainly confined to the retinal pigment epithelium and colon.
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