Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human TNFRSF4. AA range:131-180
Specificity
Ox40 Polyclonal Antibody detects endogenous levels of Ox40 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008],
Function
function:Receptor for TNFSF4/OX40L/GP34.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF2, TRAF3 and TRAF5.,
Protein name
Tumor necrosis factor receptor superfamily member 4
Other name
TNFRSF4; TXGP1L; Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD134
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P43489
Mouse protein sequence database
P47741
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.
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