Molecular weight (DA)
24kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human AICDA. AA range:81-130
Specificity
AID Polyclonal Antibody detects endogenous levels of AID protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009],
Function
catalytic activity:Cytidine + H(2)O = uridine + NH(3).,cofactor:Zinc.,disease:Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.,function:RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.,online information:AICDA mutation db,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Str
Protein name
Activation-induced cytidine deaminase
Other name
AICDA; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase
Fields
>>Intestinal immune network for IgA production;>>Primary immunodeficiency
Human protein sequence Database
Q9GZX7
Mouse protein sequence database
Q9WVE0
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Predominantly cytoplasmic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity). .
Tissue expression
Strongly expressed in lymph nodes and tonsils.
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