Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CD1E. AA range:321-370
Specificity
CD1E Polyclonal Antibody detects endogenous levels of CD1E protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been desc
Function
function:Required for the presentation of glycolipid antigens on the cell surface.,PTM:Mono-ubiquitinated.,PTM:Proteolytically cleaved in endosomes to yield a soluble form.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subcellular location:Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.,subunit:Heterodimer with B2M (beta-2-microglobulin).,tissue specificity:Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.,
Protein name
T-cell surface glycoprotein CD1e membrane-associated
Other name
CD1E; T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD1e
Fields
>>Tight junction;>>Hematopoietic cell lineage;>>Amoebiasis
Human protein sequence Database
P15812
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
Tissue expression
Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
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