Molecular weight (DA)
38kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FKBPL. AA range:251-300
Specificity
FKBPL Polyclonal Antibody detects endogenous levels of FKBPL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008],
Function
function:May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 TPR repeats.,subunit:Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.,tissue specificity:Ubiquitously expressed with higher levels in testis.,
Protein name
FK506-binding protein-like
Other name
FKBPL; DIR1; NG7; FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39
Human protein sequence Database
Q9UIM3
Mouse protein sequence database
O35450
Rat protein sequence database
Q6MG81
Cellular localization
endoplasmic reticulum membrane,cytosol,
Tissue expression
Ubiquitously expressed with higher levels in testis.
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