Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CD2 Tail-binding. AA range:101-150
Specificity
CD2BP2 Polyclonal Antibody detects endogenous levels of CD2BP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008],
Function
similarity:Contains 1 GYF domain.,subunit:Binds the cytoplasmic domain of CD2 through the GYF domain.,
Protein name
CD2 antigen cytoplasmic tail-binding protein 2
Other name
CD2BP2; KIAA1178; CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2
Human protein sequence Database
O95400
Mouse protein sequence database
Q9CWK3
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus. Predominantly nuclear.
Tissue expression
Aorta,Brain,Epithelium,Liver,Lung,
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