Molecular weight (DA)
84kD
Immunogen
Synthetic peptide from human protein at AA range: 280-340
Specificity
The antibody detects endogenous CD168
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008],
Function
function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue.,
Gene Name
HMMR IHABP RHAMM
Protein name
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)
Other name
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD antigen CD168)
Fields
>>ECM-receptor interaction
Human protein sequence Database
O75330
Mouse protein sequence database
Q00547
Rat protein sequence database
Cellular localization
Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle .
Tissue expression
Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).
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