Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2. AA range:141-190
Specificity
IL-1RII Polyclonal Antibody detects endogenous levels of IL-1RII protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012],
Function
function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1ra).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,
Protein name
Interleukin-1 receptor type 2
Other name
IL1R2; IL1RB; Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type II; CD121b
Fields
>>Cytokine-cytokine receptor interaction;>>Hematopoietic cell lineage;>>Amoebiasis;>>Human T-cell leukemia virus 1 infection;>>Transcriptional misregulation in cancer;>>Prostate cancer;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P27930
Mouse protein sequence database
P27931
Rat protein sequence database
Cellular localization
[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane; Single-pass type I membrane protein.
Tissue expression
B-cell,Colon,Ovary,
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