Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182
Specificity
RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011],
Function
function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells.,
Protein name
Advanced glycosylation end product-specific receptor
Other name
AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products
Fields
>>Neutrophil extracellular trap formation;>>AGE-RAGE signaling pathway in diabetic complications;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis
Human protein sequence Database
Q15109
Mouse protein sequence database
Q62151
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Endothelial cells.
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