Molecular weight (DA)
130kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70
Specificity
mGluR5 Polyclonal Antibody detects endogenous levels of mGluR5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Function
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,
Protein name
Metabotropic glutamate receptor 5
Other name
GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5
Fields
>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Alzheimer disease;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
P41594
Mouse protein sequence database
Q3UVX5
Rat protein sequence database
P31424
Cellular localization
Cell membrane ; Multi-pass membrane protein .
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