Immunogen
The antiserum was produced against synthesized peptide derived from human GRM1. AA range:251-300
Specificity
mGluR1 Polyclonal Antibody detects endogenous levels of mGluR1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glutamate metabotropic receptor 1(GRM1) Homo sapiens This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],
Function
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,
Protein name
Metabotropic glutamate receptor 1
Other name
GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1
Fields
>>Calcium signaling pathway;>>FoxO signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Long-term depression;>>Taste transduction;>>Estrogen signaling pathway;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases
Human protein sequence Database
Q13255
Mouse protein sequence database
P97772
Rat protein sequence database
P23385
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in brain.
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