Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247
Specificity
IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],
Function
function:Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Prostacyclin receptor
Other name
PTGIR; PRIPR; Prostacyclin receptor; Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
Fields
>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>Platelet activation
Human protein sequence Database
P43119
Mouse protein sequence database
P43252
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Lung,Pancreas,Placenta,
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