Molecular weight (DA)
68kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MTR1L. AA range:301-350
Specificity
GPR50 Polyclonal Antibody detects endogenous levels of GPR50 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010],
Function
function:Does not bind melatonin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Hypothalamus and pituitary.,
Protein name
Melatonin-related receptor
Other name
GPR50; Melatonin-related receptor; G protein-coupled receptor 50; H9
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
Q13585
Mouse protein sequence database
O88495
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Hypothalamus and pituitary.
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