Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR139. AA range:181-230
Specificity
GPR139 Polyclonal Antibody detects endogenous levels of GPR139 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
function:Orphan receptor. Seems to act through a G(q/11)-mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.,
Protein name
Probable G-protein coupled receptor 139
Other name
GPR139; GPRG1; PGR3; Probable G-protein coupled receptor 139; G(q)-coupled orphan receptor GPRg1; G-protein-coupled receptor PGR3
Human protein sequence Database
Q6DWJ6
Mouse protein sequence database
Q80UC8
Rat protein sequence database
P0C0W8
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.
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