Molecular weight (DA)
54kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GLR. AA range:95-144
Specificity
Glucagon Receptor Polyclonal Antibody detects endogenous levels of Glucagon Receptor protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glucagon receptor(GCGR) Homo sapiens The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010],
Function
disease:It is a candidate for certain defects in non-insulin-dependent diabetes mellitus (NIDDM). The variant in position 40 (Ser) is found in some NIDDM patients, but also in nondiabetic subjects.,function:This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 2 family.,
Protein name
Glucagon receptor
Abbreviation
Glucagon Receptor
Other name
GCGR; Glucagon receptor; GL-R
Fields
>>Neuroactive ligand-receptor interaction;>>Glucagon signaling pathway
Human protein sequence Database
P47871
Mouse protein sequence database
Q61606
Rat protein sequence database
P30082
Cellular localization
Cell membrane ; Multi-pass membrane protein . Is rapidly internalized after ligand-binding. .
Tissue expression
Liver,Placenta,
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