Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GLP1R. AA range:101-150
Specificity
GLP-1R Polyclonal Antibody detects endogenous levels of GLP-1R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
glucagon like peptide 1 receptor(GLP1R) Homo sapiens This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016],
Function
function:This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,online information:Glucagon-like peptide 1 entry,similarity:Belongs to the G-protein coupled receptor 2 family.,
Protein name
Glucagon-like peptide 1 receptor
Other name
GLP1R; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion
Human protein sequence Database
P43220
Mouse protein sequence database
O35659
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Gastric carcinoma,Insulinoma,Pancreas,Pancreatic islet,Placenta,
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