Molecular weight (DA)
67kD
Immunogen
Synthesized peptide derived from APP-BP2 . at AA range: 390-470
Specificity
APP-BP2 Polyclonal Antibody detects endogenous levels of APP-BP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function
function:May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.,PTM:Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.,similarity:Contains 8 TPR repeats.,subcellular location:Associated with membranes and microtubules.,subunit:Binds APP.,
Protein name
Amyloid protein-binding protein 2
Other name
APPBP2; KIAA0228; PAT1; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; APP-BP2; Protein interacting with APP tail 1
Human protein sequence Database
Q92624
Mouse protein sequence database
Q9DAX9
Rat protein sequence database
A5HK05
Cellular localization
Nucleus . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Associated with membranes and microtubules. .
Tissue expression
Bone marrow,Cervix carcinoma,Skin,
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