Molecular weight (DA)
115kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ZNF387. AA range:41-90
Specificity
ST18 Polyclonal Antibody detects endogenous levels of ST18 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.,similarity:Contains 6 C2HC-type zinc fingers.,tissue specificity:Detected at low levels in heart, liver, kidney, skeletal muscel, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.,
Function
function:Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.,similarity:Contains 6 C2HC-type zinc fingers.,tissue specificity:Detected at low levels in heart, liver, kidney, skeletal muscel, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.,
Protein name
Suppression of tumorigenicity 18 protein
Other name
ST18; KIAA0535; ZNF387; Suppression of tumorigenicity 18 protein; Zinc finger protein 387
Human protein sequence Database
O60284
Mouse protein sequence database
Q80TY4
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.