Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from human 5-HT-1B. AA range:201-250
Specificity
SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],
Function
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
5-hydroxytryptamine receptor 1B
Other name
HTR1B; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse;>>Taste transduction
Human protein sequence Database
P28222
Mouse protein sequence database
P28334
Rat protein sequence database
P28564
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
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