Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NTR2. AA range:151-200
Specificity
NTR2 Polyclonal Antibody detects endogenous levels of NTR2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008],
Function
function:Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Neurotensin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Neurotensin receptor type 2
Other name
NTSR2; Neurotensin receptor type 2; NT-R-2; NTR2; Levocabastine-sensitive neurotensin receptor
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
O95665
Mouse protein sequence database
P70310
Rat protein sequence database
Q63384
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in prostate (at protein level).
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