Immunogen
Synthesized peptide derived from Neurocalcin δ . at AA range: 370-450
Specificity
Neurocalcin δ Polyclonal Antibody detects endogenous levels of Neurocalcin δ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
Function
function:May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.,
Protein name
Neurocalcin-delta
Abbreviation
Neurocalcin δ
Other name
NCALD; Neurocalcin-delta
Fields
>>Olfactory transduction
Human protein sequence Database
P61601
Mouse protein sequence database
Q91X97
Rat protein sequence database
Q5PQN0
Cellular localization
intracellular,cytosol,clathrin coat of trans-Golgi network vesicle,extracellular exosome,
Tissue expression
Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
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