Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190
Specificity
GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,
Protein name
GDNF family receptor alpha-4
Other name
GFRA4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor
Human protein sequence Database
Q9GZZ7
Mouse protein sequence database
Q9JJT2
Rat protein sequence database
Cellular localization
[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
Tissue expression
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
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