Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DRD1. AA range:135-184
Specificity
D1DR Polyclonal Antibody detects endogenous levels of D1DR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008],
Function
function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.,subunit:Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.,tissue specificity:Detected in caudate, nucleus accumbens and in the olfactory tubercle.,
Protein name
D(1A) dopamine receptor
Other name
DRD1; D(1A) dopamine receptor; Dopamine D1 receptor
Fields
>>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Morphine addiction;>>Alcoholism
Human protein sequence Database
P21728
Mouse protein sequence database
Q61616
Rat protein sequence database
P18901
Cellular localization
Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. .
Tissue expression
Detected in caudate, nucleus accumbens and in the olfactory tubercle.
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