Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CBLN1. AA range:131-180
Specificity
Cerebellin 1 Polyclonal Antibody detects endogenous levels of Cerebellin 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008],
Function
developmental stage:Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.,function:Cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.,function:Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.,PTM:The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.,similarity:Contains 1 C1q domain.,subcellular location:Might be bound to, or associated with, a membrane.,subunit:Homohexamer;
Protein name
Cerebellin-1
Abbreviation
Cerebellin 1
Other name
CBLN1; Cerebellin-1; Precerebellin
Human protein sequence Database
P23435
Mouse protein sequence database
Q9R171
Rat protein sequence database
P63182
Cellular localization
Secreted . Cell junction, synapse, postsynaptic cell membrane .
Tissue expression
In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.
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