Molecular weight (DA)
78kD
Immunogen
Synthesized peptide derived from human Secretogranin-1
Specificity
This antibody detects endogenous levels of human Secretogranin-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009],
Function
function:Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.,PTM:Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues.,similarity:Belongs to the chromogranin/secretogranin protein family.,subcellular location:Neuroendocrine and endocrine secretory granules.,tissue specificity:Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.,
Protein name
Secretogranin-1
Abbreviation
Secretogranin-1
Other name
Secretogranin-1 (Chromogranin-B;CgB;Secretogranin I;SgI) [Cleaved into: GAWK peptide; CCB peptide]
Human protein sequence Database
P05060
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted. Neuroendocrine and endocrine secretory granules.
Tissue expression
Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
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