Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from human LSHR Polyclonal
Specificity
This antibody detects endogenous levels of LSHR.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist,disease:Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.,disease:Defects in LHCGR are a cause of Leydig cell hypoplasia (LCH) [MIM:152790]. LCH is an autosomal recessive disease characterized by male pseudohermaphroditism. In LCH the testes are small with marked immaturity of the Leydig cells which correlates with undetectable plasma testosterone levels and elevated gonadotropins.,function:Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.,online information:Glycoprotein-hormone Receptors Information System,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family.
Gene Name
LHCGR LCGR LGR2 LHRHR
Protein name
Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
Other name
Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R)
Fields
>>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Ovarian steroidogenesis;>>Prolactin signaling pathway
Human protein sequence Database
P22888
Mouse protein sequence database
P30730
Rat protein sequence database
P16235
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Gonadal and thyroid cells.
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