Immunogen
Synthetic peptide from human protein at AA range: 81-130
Specificity
The antibody detects endogenous IL-17F
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008],
Function
function:Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.,online information:Interleukin-17 entry,similarity:Belongs to the IL-17 family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.,
Protein name
Interleukin-17F (IL-17F) (Cytokine ML-1) (Interleukin-24) (IL-24)
Other name
Interleukin-17F (IL-17F;Cytokine ML-1;Interleukin-24;IL-24)
Fields
>>Cytokine-cytokine receptor interaction;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Inflammatory bowel disease
Human protein sequence Database
Q96PD4
Mouse protein sequence database
Q7TNI7
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in T-helper 1 and T-helper 2 cells, basophils and mast cells.
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