Immunogen
Synthetic peptide from human protein at AA range: 101-150
Specificity
The antibody detects endogenous CD231
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008],
Function
disease:Defects in TSPAN7 are the cause of mental retardation X-linked type 58 (MRX58) [MIM:300210]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,function:May be involved in cell proliferation and cell motility.,similarity:Belongs to the tetraspanin (TM4SF) family.,tissue specificity:Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.,
Gene Name
TSPAN7 A15 DXS1692E MXS1 TM4SF2
Protein name
Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfa
Other name
Tetraspanin-7 (Tspan-7;Cell surface glycoprotein A15;Membrane component chromosome X surface marker 1;T-cell acute lymphoblastic leukemia-associated antigen 1;TALLA-1;Transmembrane 4 superfamily member 2;CD antigen CD231)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
P41732
Mouse protein sequence database
Q62283
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
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