Molecular weight (DA)
20kD
Immunogen
Synthetic peptide from human protein at AA range: 51-100
Specificity
The antibody detects endogenous IL-19
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008],
Function
function:May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.,similarity:Belongs to the IL-10 family.,
Protein name
Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)
Other name
Interleukin-19 (IL-19;Melanoma differentiation-associated protein-like protein;NG.1)
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>JAK-STAT signaling pathway
Human protein sequence Database
Q9UHD0
Mouse protein sequence database
Q8CJ70
Rat protein sequence database
Cellular localization
Secreted.
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