Molecular weight (DA)
220kD
Immunogen
Synthesized peptide derived from human GARNL1 (Phospho-S797)
Specificity
This antibody detects endogenous phospho levels of GARNL1 (Phospho-S797) at Human, Mouse, Rat
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016],
Function
regulation of small GTPase mediated signal transduction,
Gene Name
RALGAPA1 GARNL1 KIAA0884 TULIP1
Protein name
GARNL1 (Phospho-S797)
Other name
Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12;GRIPE;GTPase-activating Rap/Ran-GAP domain-like 1;Tuberin-like protein 1;p240)
Fields
>>Ras signaling pathway
Human protein sequence Database
Q6GYQ0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Translocated to the nucleus, when associated with TCF3/E12. .
Tissue expression
Widely expressed.
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