Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from human MLKL (phospho S358)
Specificity
This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Function
domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
MLKL (phospho S358)
Other name
Mixed lineage kinase domain-like protein
Fields
>>Necroptosis;>>TNF signaling pathway;>>Salmonella infection
Human protein sequence Database
Q8NB16
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
Tissue expression
Chondrocyte,Leukocyte,Lymph node,
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