Molecular weight (DA)
48kD
Immunogen
Synthesized peptide derived from human MOK (Phospho-Tyr161)
Specificity
This antibody detects endogenous phospho levels of MOK (Phospho-Tyr161) at Human:Y161, Mouse:Y161, Rat:Y161
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
MOK protein kinase(MOK) Homo sapiens This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation appears to increase the enzymatic activity.,function:Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.,
Protein name
MOK (Phospho-Tyr161)
Other name
MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22;MOK protein kinase;Renal tumor antigen 1;RAGE-1)
Human protein sequence Database
Q9UQ07
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Cell projection, cilium . Nucleus .
Tissue expression
Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
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