Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DLL4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008],
Function
domain:The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.,function:Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.,PTM:Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.,similarity:Contains 1 DSL domain.,similarity:Contains 8 EGF-like domains.,subunit:Binds to Notch-1 and Notch-4.,tissue specificity:Expressed in vascular endothelium.,
Gene Name
DLL4 UNQ1895/PRO4341
Protein name
Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4)
Fields
>>Endocrine resistance;>>Notch signaling pathway;>>Th1 and Th2 cell differentiation;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Breast cancer
Human protein sequence Database
Q9NR61
Mouse protein sequence database
Q9JI71
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed in vascular endothelium.
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