Molecular weight (DA)
59kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MPP6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008],
Function
similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 L27 domains.,subunit:Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.,tissue specificity:Abundant in testis, brain, and kidney with lower levels detectable in other tissues.,
Protein name
MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1)
Human protein sequence Database
Q9NZW5
Mouse protein sequence database
Q9JLB0
Rat protein sequence database
Cellular localization
Membrane ; Peripheral membrane protein .
Tissue expression
Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
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