Molecular weight (DA)
279kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MUC3A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008],
Function
alternative products:Additional isoforms seem to exist,function:Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.,function:Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.,PTM:Highly O-glycosylated and probably also N-glycosylated.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 SEA domain.,tissue specificity:Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.,tissue specificity:Fetal and adult small intestine and fetal and adult colon.,
Protein name
Mucin-3A (MUC-3A) (Intestinal mucin-3A)
Human protein sequence Database
Q02505
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Isoform 1]: Membrane; Single-pass membrane protein .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 5]: Secreted.
Tissue expression
Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
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