Molecular weight (DA)
28kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
S5A1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008],
Function
catalytic activity:A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.,function:Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.,induction:Its expression is regulated by androgens such as testosterone.,online information:5-alpha reductase entry,similarity:Belongs to the steroid 5-alpha reductase family.,tissue specificity:Liver and prostate (at a low level).,
Protein name
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.30) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)
Fields
>>Steroid hormone biosynthesis;>>Metabolic pathways
Human protein sequence Database
P18405
Mouse protein sequence database
Q68FF9
Rat protein sequence database
P24008
Cellular localization
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Liver and prostate (at a low level).
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