Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from part region of human protein. AA range 1-38
Specificity
PACA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC-p 1:50-300 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013],
Function
function:Stimulates adenylate cyclase in pituitary cells.,similarity:Belongs to the glucagon family.,
Protein name
Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylat
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Circadian entrainment;>>Insulin secretion;>>Renin secretion
Human protein sequence Database
P18509
Mouse protein sequence database
O70176
Rat protein sequence database
P13589
Cellular localization
Secreted.
Tissue expression
Brain,Testis,
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