Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 404-454
Specificity
ARI3A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008],
Function
function:Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.,induction:By TP53 following DNA damage.,similarity:Contains 1 ARID domain.,similarity:Contains 1 NAP (nucleosome assembly protein) domain.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.,tissue specificity:Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.,
Gene Name
ARID3A DRIL1 DRIL3 DRX E2FBP1
Protein name
AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)
Human protein sequence Database
Q99856
Mouse protein sequence database
Q62431
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Shuttles between nucleus and cytoplasm.
Tissue expression
Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
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